The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study in a Demanding Set of Cases.
Identifieur interne : 000249 ( Main/Exploration ); précédent : 000248; suivant : 000250The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study in a Demanding Set of Cases.
Auteurs : Erik Thunnissen [Pays-Bas] ; Alain C. Borczuk [États-Unis] ; Douglas B. Flieder [États-Unis] ; Birgit Witte [Pays-Bas] ; Mary Beth Beasley [États-Unis] ; Jin-Haeng Chung [Corée du Sud] ; Sanja Dacic [États-Unis] ; Sylvie Lantuejoul [France] ; Prudence A. Russell [Australie] ; Michael Den Bakker [Pays-Bas] ; Johan Botling [Suède] ; Elisabeth Brambilla [France] ; Erienne De Cuba [Pays-Bas] ; Kim R. Geisinger [États-Unis] ; Kenzo Hiroshima [Japon] ; Alberto M. Marchevsky [États-Unis] ; Yuko Minami [Japon] ; Andre Moreira [États-Unis] ; Andrew G. Nicholson [Royaume-Uni] ; Akihiko Yoshida [Japon] ; Ming-Sound Tsao [Canada] ; Arne Warth [Allemagne] ; Edwina Duhig [Australie] ; Gang Chen [République populaire de Chine] ; Yoshihiro Matsuno [Japon] ; William D. Travis [États-Unis] ; Kelly Butnor [États-Unis] ; Wendy Cooper [Australie] ; Mari Mino-Kenudson [États-Unis] ; Noriko Motoi [Japon] ; Claudia Poleri [Argentine] ; Giuseppe Pelosi [Italie] ; Keith Kerr [Royaume-Uni] ; Seena C. Aisner [États-Unis] ; Yuichi Ishikawa [Japon] ; Reinhard H. Buettner [Allemagne] ; Naoto Keino [Japon] ; Yasushi Yatabe [Japon] ; Masayuki Noguchi [Japon]Source :
- Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [ 1556-1380 ] ; 2017.
Abstract
The current WHO classification of lung cancer states that a diagnosis of SCLC can be reliably made on routine histological and cytological grounds but immunohistochemistry (IHC) may be required, particularly (1) in cases in which histologic features are equivocal and (2) in cases in which the pathologist wants to increase confidence in diagnosis. However, reproducibility studies based on hematoxylin and eosin-stained slides alone for SCLC versus large cell neuroendocrine carcinoma (LCNEC) have shown pairwise κ scores ranging from 0.35 to 0.81. This study examines whether judicious use of IHC improves diagnostic reproducibility for SCLC.
DOI: 10.1016/j.jtho.2016.12.004
PubMed: 27998793
Affiliations:
- Allemagne, Argentine, Australie, Canada, Corée du Sud, France, Italie, Japon, Pays-Bas, Royaume-Uni, République populaire de Chine, Suède, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Bade-Wurtemberg, Californie, District de Cologne, District de Karlsruhe, East Middle Sweden, Grand Londres, Hollande-Méridionale, Hollande-Septentrionale, Lombardie, Massachusetts, New Jersey, Pennsylvanie, Rhénanie-du-Nord-Westphalie, Rhône-Alpes, Région de Kantō, Svealand, Vermont, Victoria (État), État de New York, État du Mississippi
- Amsterdam, Cologne, Grenoble, Heidelberg, Londres, Lyon, Melbourne, Milan, Rotterdam, Tokyo, Uppsala
- Université d'Uppsala, Université de Melbourne
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Electronic address: e.thunnissen@vumc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Borczuk, Alain C" sort="Borczuk, Alain C" uniqKey="Borczuk A" first="Alain C" last="Borczuk">Alain C. Borczuk</name><affiliation wicri:level="2"><nlm:affiliation>Deptartment of Pathology, Weill Cornell Medicine, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Deptartment of Pathology, Weill Cornell Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Flieder, Douglas B" sort="Flieder, Douglas B" uniqKey="Flieder D" first="Douglas B" last="Flieder">Douglas B. 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Russell</name><affiliation wicri:level="4"><nlm:affiliation>St. Vincent's Pathology and The University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St. Vincent's Pathology and The University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Den Bakker, Michael" sort="Den Bakker, Michael" uniqKey="Den Bakker M" first="Michael" last="Den Bakker">Michael Den Bakker</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Maasstad Ziekenhuis, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Pathology, Maasstad Ziekenhuis, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Botling, Johan" sort="Botling, Johan" uniqKey="Botling J" first="Johan" last="Botling">Johan Botling</name><affiliation wicri:level="4"><nlm:affiliation>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Brambilla, Elisabeth" sort="Brambilla, Elisabeth" uniqKey="Brambilla E" first="Elisabeth" last="Brambilla">Elisabeth Brambilla</name><affiliation wicri:level="3"><nlm:affiliation>CHU Albert Michallon-Institut de Biologie, Département d'Anatomie et Cytologie Pathologiques, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Albert Michallon-Institut de Biologie, Département d'Anatomie et Cytologie Pathologiques, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="De Cuba, Erienne" sort="De Cuba, Erienne" uniqKey="De Cuba E" first="Erienne" last="De Cuba">Erienne De Cuba</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Geisinger, Kim R" sort="Geisinger, Kim R" uniqKey="Geisinger K" first="Kim R" last="Geisinger">Kim R. Geisinger</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>Department of Pathology, The University of Mississippi Medical Center, Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Hiroshima, Kenzo" sort="Hiroshima, Kenzo" uniqKey="Hiroshima K" first="Kenzo" last="Hiroshima">Kenzo Hiroshima</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Tokyo Women's Medical University, Yachiyo Medical Center, Yachiyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Tokyo Women's Medical University, Yachiyo Medical Center, Yachiyo</wicri:regionArea><wicri:noRegion>Yachiyo</wicri:noRegion></affiliation></author><author><name sortKey="Marchevsky, Alberto M" sort="Marchevsky, Alberto M" uniqKey="Marchevsky A" first="Alberto M" last="Marchevsky">Alberto M. Marchevsky</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Cedars Sinai Medical Center, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Cedars Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Minami, Yuko" sort="Minami, Yuko" uniqKey="Minami Y" first="Yuko" last="Minami">Yuko Minami</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba</wicri:regionArea><wicri:noRegion>Tsukuba</wicri:noRegion></affiliation></author><author><name sortKey="Moreira, Andre" sort="Moreira, Andre" uniqKey="Moreira A" first="Andre" last="Moreira">Andre Moreira</name><affiliation wicri:level="2"><nlm:affiliation>Pulmonary Pathology, New York University Center for Biospecimen Research and Development, New York University, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Pulmonary Pathology, New York University Center for Biospecimen Research and Development, New York University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Nicholson, Andrew G" sort="Nicholson, Andrew G" uniqKey="Nicholson A" first="Andrew G" last="Nicholson">Andrew G. Nicholson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Histopathology, Royal Brompton and Harefield Hospitals National Health Service Foundation Trust and National Heart and Lung Institute, Imperial College, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Histopathology, Royal Brompton and Harefield Hospitals National Health Service Foundation Trust and National Heart and Lung Institute, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Yoshida, Akihiko" sort="Yoshida, Akihiko" uniqKey="Yoshida A" first="Akihiko" last="Yoshida">Akihiko Yoshida</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Tsao, Ming Sound" sort="Tsao, Ming Sound" uniqKey="Tsao M" first="Ming-Sound" last="Tsao">Ming-Sound Tsao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Health Network-Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology, University Health Network-Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Warth, Arne" sort="Warth, Arne" uniqKey="Warth A" first="Arne" last="Warth">Arne Warth</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pathology, Heidelberg University, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Heidelberg University, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Duhig, Edwina" sort="Duhig, Edwina" uniqKey="Duhig E" first="Edwina" last="Duhig">Edwina Duhig</name><affiliation wicri:level="1"><nlm:affiliation>Sullivan Nicolaides Pathology, The John Flynn Hospital, Tugun, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sullivan Nicolaides Pathology, The John Flynn Hospital, Tugun, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Gang" sort="Chen, Gang" uniqKey="Chen G" first="Gang" last="Chen">Gang Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Matsuno, Yoshihiro" sort="Matsuno, Yoshihiro" uniqKey="Matsuno Y" first="Yoshihiro" last="Matsuno">Yoshihiro Matsuno</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgical Pathology, Hokkaido University Hospital, Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author><author><name sortKey="Travis, William D" sort="Travis, William D" uniqKey="Travis W" first="William D" last="Travis">William D. Travis</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Butnor, Kelly" sort="Butnor, Kelly" uniqKey="Butnor K" first="Kelly" last="Butnor">Kelly Butnor</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Cooper, Wendy" sort="Cooper, Wendy" uniqKey="Cooper W" first="Wendy" last="Cooper">Wendy Cooper</name><affiliation wicri:level="1"><nlm:affiliation>Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Mino Kenudson, Mari" sort="Mino Kenudson, Mari" uniqKey="Mino Kenudson M" first="Mari" last="Mino-Kenudson">Mari Mino-Kenudson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Motoi, Noriko" sort="Motoi, Noriko" uniqKey="Motoi N" first="Noriko" last="Motoi">Noriko Motoi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Poleri, Claudia" sort="Poleri, Claudia" uniqKey="Poleri C" first="Claudia" last="Poleri">Claudia Poleri</name><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Patología Torácica, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratorio de Patología Torácica, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Pelosi, Giuseppe" sort="Pelosi, Giuseppe" uniqKey="Pelosi G" first="Giuseppe" last="Pelosi">Giuseppe Pelosi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Kerr, Keith" sort="Kerr, Keith" uniqKey="Kerr K" first="Keith" last="Kerr">Keith Kerr</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, Aberdeen Royal Infirmary, Aberdeen</wicri:regionArea><wicri:noRegion>Aberdeen</wicri:noRegion></affiliation></author><author><name sortKey="Aisner, Seena C" sort="Aisner, Seena C" uniqKey="Aisner S" first="Seena C" last="Aisner">Seena C. Aisner</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine at Rutgers New Jersey Medical School, Rutgers University, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine at Rutgers New Jersey Medical School, Rutgers University, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Ishikawa, Yuichi" sort="Ishikawa, Yuichi" uniqKey="Ishikawa Y" first="Yuichi" last="Ishikawa">Yuichi Ishikawa</name><affiliation wicri:level="3"><nlm:affiliation>Division of Pathology, The Cancer Institute, Japan Foundation Cancer Research, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Pathology, The Cancer Institute, Japan Foundation Cancer Research, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Buettner, Reinhard H" sort="Buettner, Reinhard H" uniqKey="Buettner R" first="Reinhard H" last="Buettner">Reinhard H. Buettner</name><affiliation wicri:level="3"><nlm:affiliation>Cologne Institute for Pathology, Köln, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne Institute for Pathology, Köln</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Keino, Naoto" sort="Keino, Naoto" uniqKey="Keino N" first="Naoto" last="Keino">Naoto Keino</name><affiliation wicri:level="1"><nlm:affiliation>Tsukuba Clinical Research and Development Organization, University of Tsukuba, Tsukuba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tsukuba Clinical Research and Development Organization, University of Tsukuba, Tsukuba</wicri:regionArea><wicri:noRegion>Tsukuba</wicri:noRegion></affiliation></author><author><name sortKey="Yatabe, Yasushi" sort="Yatabe, Yasushi" uniqKey="Yatabe Y" first="Yasushi" last="Yatabe">Yasushi Yatabe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya</wicri:regionArea><wicri:noRegion>Nagoya</wicri:noRegion></affiliation></author><author><name sortKey="Noguchi, Masayuki" sort="Noguchi, Masayuki" uniqKey="Noguchi M" first="Masayuki" last="Noguchi">Masayuki Noguchi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba</wicri:regionArea><wicri:noRegion>Tsukuba</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27998793</idno><idno type="pmid">27998793</idno><idno type="doi">10.1016/j.jtho.2016.12.004</idno><idno type="wicri:Area/PubMed/Corpus">001099</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001099</idno><idno type="wicri:Area/PubMed/Curation">001096</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001096</idno><idno type="wicri:Area/PubMed/Checkpoint">001096</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001096</idno><idno type="wicri:Area/Ncbi/Merge">004067</idno><idno type="wicri:Area/Ncbi/Curation">004067</idno><idno type="wicri:Area/Ncbi/Checkpoint">004067</idno><idno type="wicri:Area/Main/Merge">000244</idno><idno type="wicri:Area/Main/Curation">000249</idno><idno type="wicri:Area/Main/Exploration">000249</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study in a Demanding Set of Cases.</title><author><name sortKey="Thunnissen, Erik" sort="Thunnissen, Erik" uniqKey="Thunnissen E" first="Erik" last="Thunnissen">Erik Thunnissen</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: e.thunnissen@vumc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Borczuk, Alain C" sort="Borczuk, Alain C" uniqKey="Borczuk A" first="Alain C" last="Borczuk">Alain C. Borczuk</name><affiliation wicri:level="2"><nlm:affiliation>Deptartment of Pathology, Weill Cornell Medicine, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Deptartment of Pathology, Weill Cornell Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Flieder, Douglas B" sort="Flieder, Douglas B" uniqKey="Flieder D" first="Douglas B" last="Flieder">Douglas B. Flieder</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology, Fox Chase Cancer Center, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Witte, Birgit" sort="Witte, Birgit" uniqKey="Witte B" first="Birgit" last="Witte">Birgit Witte</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Beasley, Mary Beth" sort="Beasley, Mary Beth" uniqKey="Beasley M" first="Mary Beth" last="Beasley">Mary Beth Beasley</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Mount Sinai Medical Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pathology, Mount Sinai Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Chung, Jin Haeng" sort="Chung, Jin Haeng" uniqKey="Chung J" first="Jin-Haeng" last="Chung">Jin-Haeng Chung</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital</wicri:regionArea><wicri:noRegion>Seoul National University Bundang Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Dacic, Sanja" sort="Dacic, Sanja" uniqKey="Dacic S" first="Sanja" last="Dacic">Sanja Dacic</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology University of Pittsburgh, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Pathology University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Lantuejoul, Sylvie" sort="Lantuejoul, Sylvie" uniqKey="Lantuejoul S" first="Sylvie" last="Lantuejoul">Sylvie Lantuejoul</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biopathology, Centre Léon Bérard UNICANCER, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Biopathology, Centre Léon Bérard UNICANCER, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Russell, Prudence A" sort="Russell, Prudence A" uniqKey="Russell P" first="Prudence A" last="Russell">Prudence A. Russell</name><affiliation wicri:level="4"><nlm:affiliation>St. Vincent's Pathology and The University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>St. Vincent's Pathology and The University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Den Bakker, Michael" sort="Den Bakker, Michael" uniqKey="Den Bakker M" first="Michael" last="Den Bakker">Michael Den Bakker</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Maasstad Ziekenhuis, Rotterdam, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Pathology, Maasstad Ziekenhuis, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Botling, Johan" sort="Botling, Johan" uniqKey="Botling J" first="Johan" last="Botling">Johan Botling</name><affiliation wicri:level="4"><nlm:affiliation>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Brambilla, Elisabeth" sort="Brambilla, Elisabeth" uniqKey="Brambilla E" first="Elisabeth" last="Brambilla">Elisabeth Brambilla</name><affiliation wicri:level="3"><nlm:affiliation>CHU Albert Michallon-Institut de Biologie, Département d'Anatomie et Cytologie Pathologiques, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHU Albert Michallon-Institut de Biologie, Département d'Anatomie et Cytologie Pathologiques, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="De Cuba, Erienne" sort="De Cuba, Erienne" uniqKey="De Cuba E" first="Erienne" last="De Cuba">Erienne De Cuba</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Geisinger, Kim R" sort="Geisinger, Kim R" uniqKey="Geisinger K" first="Kim R" last="Geisinger">Kim R. Geisinger</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, The University of Mississippi Medical Center, Jackson, Mississippi.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>Department of Pathology, The University of Mississippi Medical Center, Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Hiroshima, Kenzo" sort="Hiroshima, Kenzo" uniqKey="Hiroshima K" first="Kenzo" last="Hiroshima">Kenzo Hiroshima</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Tokyo Women's Medical University, Yachiyo Medical Center, Yachiyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Tokyo Women's Medical University, Yachiyo Medical Center, Yachiyo</wicri:regionArea><wicri:noRegion>Yachiyo</wicri:noRegion></affiliation></author><author><name sortKey="Marchevsky, Alberto M" sort="Marchevsky, Alberto M" uniqKey="Marchevsky A" first="Alberto M" last="Marchevsky">Alberto M. Marchevsky</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Cedars Sinai Medical Center, Los Angeles, California.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, Cedars Sinai Medical Center, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Minami, Yuko" sort="Minami, Yuko" uniqKey="Minami Y" first="Yuko" last="Minami">Yuko Minami</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba</wicri:regionArea><wicri:noRegion>Tsukuba</wicri:noRegion></affiliation></author><author><name sortKey="Moreira, Andre" sort="Moreira, Andre" uniqKey="Moreira A" first="Andre" last="Moreira">Andre Moreira</name><affiliation wicri:level="2"><nlm:affiliation>Pulmonary Pathology, New York University Center for Biospecimen Research and Development, New York University, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Pulmonary Pathology, New York University Center for Biospecimen Research and Development, New York University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Nicholson, Andrew G" sort="Nicholson, Andrew G" uniqKey="Nicholson A" first="Andrew G" last="Nicholson">Andrew G. Nicholson</name><affiliation wicri:level="3"><nlm:affiliation>Department of Histopathology, Royal Brompton and Harefield Hospitals National Health Service Foundation Trust and National Heart and Lung Institute, Imperial College, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Histopathology, Royal Brompton and Harefield Hospitals National Health Service Foundation Trust and National Heart and Lung Institute, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Yoshida, Akihiko" sort="Yoshida, Akihiko" uniqKey="Yoshida A" first="Akihiko" last="Yoshida">Akihiko Yoshida</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Tsao, Ming Sound" sort="Tsao, Ming Sound" uniqKey="Tsao M" first="Ming-Sound" last="Tsao">Ming-Sound Tsao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, University Health Network-Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology, University Health Network-Princess Margaret Hospital and University of Toronto, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Warth, Arne" sort="Warth, Arne" uniqKey="Warth A" first="Arne" last="Warth">Arne Warth</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pathology, Heidelberg University, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Heidelberg University, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Duhig, Edwina" sort="Duhig, Edwina" uniqKey="Duhig E" first="Edwina" last="Duhig">Edwina Duhig</name><affiliation wicri:level="1"><nlm:affiliation>Sullivan Nicolaides Pathology, The John Flynn Hospital, Tugun, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sullivan Nicolaides Pathology, The John Flynn Hospital, Tugun, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Gang" sort="Chen, Gang" uniqKey="Chen G" first="Gang" last="Chen">Gang Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Matsuno, Yoshihiro" sort="Matsuno, Yoshihiro" uniqKey="Matsuno Y" first="Yoshihiro" last="Matsuno">Yoshihiro Matsuno</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgical Pathology, Hokkaido University Hospital, Sapporo</wicri:regionArea><wicri:noRegion>Sapporo</wicri:noRegion></affiliation></author><author><name sortKey="Travis, William D" sort="Travis, William D" uniqKey="Travis W" first="William D" last="Travis">William D. Travis</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pathology, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Butnor, Kelly" sort="Butnor, Kelly" uniqKey="Butnor K" first="Kelly" last="Butnor">Kelly Butnor</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Cooper, Wendy" sort="Cooper, Wendy" uniqKey="Cooper W" first="Wendy" last="Cooper">Wendy Cooper</name><affiliation wicri:level="1"><nlm:affiliation>Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Mino Kenudson, Mari" sort="Mino Kenudson, Mari" uniqKey="Mino Kenudson M" first="Mari" last="Mino-Kenudson">Mari Mino-Kenudson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Motoi, Noriko" sort="Motoi, Noriko" uniqKey="Motoi N" first="Noriko" last="Motoi">Noriko Motoi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Poleri, Claudia" sort="Poleri, Claudia" uniqKey="Poleri C" first="Claudia" last="Poleri">Claudia Poleri</name><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Patología Torácica, Buenos Aires, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratorio de Patología Torácica, Buenos Aires</wicri:regionArea><wicri:noRegion>Buenos Aires</wicri:noRegion></affiliation></author><author><name sortKey="Pelosi, Giuseppe" sort="Pelosi, Giuseppe" uniqKey="Pelosi G" first="Giuseppe" last="Pelosi">Giuseppe Pelosi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Kerr, Keith" sort="Kerr, Keith" uniqKey="Kerr K" first="Keith" last="Kerr">Keith Kerr</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, Aberdeen Royal Infirmary, Aberdeen</wicri:regionArea><wicri:noRegion>Aberdeen</wicri:noRegion></affiliation></author><author><name sortKey="Aisner, Seena C" sort="Aisner, Seena C" uniqKey="Aisner S" first="Seena C" last="Aisner">Seena C. Aisner</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine at Rutgers New Jersey Medical School, Rutgers University, Newark, New Jersey.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine at Rutgers New Jersey Medical School, Rutgers University, Newark</wicri:cityArea></affiliation></author><author><name sortKey="Ishikawa, Yuichi" sort="Ishikawa, Yuichi" uniqKey="Ishikawa Y" first="Yuichi" last="Ishikawa">Yuichi Ishikawa</name><affiliation wicri:level="3"><nlm:affiliation>Division of Pathology, The Cancer Institute, Japan Foundation Cancer Research, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Pathology, The Cancer Institute, Japan Foundation Cancer Research, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Buettner, Reinhard H" sort="Buettner, Reinhard H" uniqKey="Buettner R" first="Reinhard H" last="Buettner">Reinhard H. Buettner</name><affiliation wicri:level="3"><nlm:affiliation>Cologne Institute for Pathology, Köln, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Cologne Institute for Pathology, Köln</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Keino, Naoto" sort="Keino, Naoto" uniqKey="Keino N" first="Naoto" last="Keino">Naoto Keino</name><affiliation wicri:level="1"><nlm:affiliation>Tsukuba Clinical Research and Development Organization, University of Tsukuba, Tsukuba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tsukuba Clinical Research and Development Organization, University of Tsukuba, Tsukuba</wicri:regionArea><wicri:noRegion>Tsukuba</wicri:noRegion></affiliation></author><author><name sortKey="Yatabe, Yasushi" sort="Yatabe, Yasushi" uniqKey="Yatabe Y" first="Yasushi" last="Yatabe">Yasushi Yatabe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya</wicri:regionArea><wicri:noRegion>Nagoya</wicri:noRegion></affiliation></author><author><name sortKey="Noguchi, Masayuki" sort="Noguchi, Masayuki" uniqKey="Noguchi M" first="Masayuki" last="Noguchi">Masayuki Noguchi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba</wicri:regionArea><wicri:noRegion>Tsukuba</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer</title><idno type="eISSN">1556-1380</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The current WHO classification of lung cancer states that a diagnosis of SCLC can be reliably made on routine histological and cytological grounds but immunohistochemistry (IHC) may be required, particularly (1) in cases in which histologic features are equivocal and (2) in cases in which the pathologist wants to increase confidence in diagnosis. However, reproducibility studies based on hematoxylin and eosin-stained slides alone for SCLC versus large cell neuroendocrine carcinoma (LCNEC) have shown pairwise κ scores ranging from 0.35 to 0.81. This study examines whether judicious use of IHC improves diagnostic reproducibility for SCLC.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Argentine</li><li>Australie</li><li>Canada</li><li>Corée du Sud</li><li>France</li><li>Italie</li><li>Japon</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Californie</li><li>District de Cologne</li><li>District de Karlsruhe</li><li>East Middle Sweden</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Lombardie</li><li>Massachusetts</li><li>New Jersey</li><li>Pennsylvanie</li><li>Rhénanie-du-Nord-Westphalie</li><li>Rhône-Alpes</li><li>Région de Kantō</li><li>Svealand</li><li>Vermont</li><li>Victoria (État)</li><li>État de New York</li><li>État du Mississippi</li></region><settlement><li>Amsterdam</li><li>Cologne</li><li>Grenoble</li><li>Heidelberg</li><li>Londres</li><li>Lyon</li><li>Melbourne</li><li>Milan</li><li>Rotterdam</li><li>Tokyo</li><li>Uppsala</li></settlement><orgName><li>Université d'Uppsala</li><li>Université de Melbourne</li></orgName></list><tree><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Thunnissen, Erik" sort="Thunnissen, Erik" uniqKey="Thunnissen E" first="Erik" last="Thunnissen">Erik Thunnissen</name></region><name sortKey="De Cuba, Erienne" sort="De Cuba, Erienne" uniqKey="De Cuba E" first="Erienne" last="De Cuba">Erienne De Cuba</name><name sortKey="Den Bakker, Michael" sort="Den Bakker, Michael" uniqKey="Den Bakker M" first="Michael" last="Den Bakker">Michael Den Bakker</name><name sortKey="Witte, Birgit" sort="Witte, Birgit" uniqKey="Witte B" first="Birgit" last="Witte">Birgit Witte</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Borczuk, Alain C" sort="Borczuk, Alain C" uniqKey="Borczuk A" first="Alain C" last="Borczuk">Alain C. Borczuk</name></region><name sortKey="Aisner, Seena C" sort="Aisner, Seena C" uniqKey="Aisner S" first="Seena C" last="Aisner">Seena C. Aisner</name><name sortKey="Beasley, Mary Beth" sort="Beasley, Mary Beth" uniqKey="Beasley M" first="Mary Beth" last="Beasley">Mary Beth Beasley</name><name sortKey="Butnor, Kelly" sort="Butnor, Kelly" uniqKey="Butnor K" first="Kelly" last="Butnor">Kelly Butnor</name><name sortKey="Dacic, Sanja" sort="Dacic, Sanja" uniqKey="Dacic S" first="Sanja" last="Dacic">Sanja Dacic</name><name sortKey="Flieder, Douglas B" sort="Flieder, Douglas B" uniqKey="Flieder D" first="Douglas B" last="Flieder">Douglas B. Flieder</name><name sortKey="Geisinger, Kim R" sort="Geisinger, Kim R" uniqKey="Geisinger K" first="Kim R" last="Geisinger">Kim R. Geisinger</name><name sortKey="Marchevsky, Alberto M" sort="Marchevsky, Alberto M" uniqKey="Marchevsky A" first="Alberto M" last="Marchevsky">Alberto M. Marchevsky</name><name sortKey="Mino Kenudson, Mari" sort="Mino Kenudson, Mari" uniqKey="Mino Kenudson M" first="Mari" last="Mino-Kenudson">Mari Mino-Kenudson</name><name sortKey="Moreira, Andre" sort="Moreira, Andre" uniqKey="Moreira A" first="Andre" last="Moreira">Andre Moreira</name><name sortKey="Travis, William D" sort="Travis, William D" uniqKey="Travis W" first="William D" last="Travis">William D. Travis</name></country><country name="Corée du Sud"><noRegion><name sortKey="Chung, Jin Haeng" sort="Chung, Jin Haeng" uniqKey="Chung J" first="Jin-Haeng" last="Chung">Jin-Haeng Chung</name></noRegion></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Lantuejoul, Sylvie" sort="Lantuejoul, Sylvie" uniqKey="Lantuejoul S" first="Sylvie" last="Lantuejoul">Sylvie Lantuejoul</name></region><name sortKey="Brambilla, Elisabeth" sort="Brambilla, Elisabeth" uniqKey="Brambilla E" first="Elisabeth" last="Brambilla">Elisabeth Brambilla</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Russell, Prudence A" sort="Russell, Prudence A" uniqKey="Russell P" first="Prudence A" last="Russell">Prudence A. Russell</name></region><name sortKey="Cooper, Wendy" sort="Cooper, Wendy" uniqKey="Cooper W" first="Wendy" last="Cooper">Wendy Cooper</name><name sortKey="Duhig, Edwina" sort="Duhig, Edwina" uniqKey="Duhig E" first="Edwina" last="Duhig">Edwina Duhig</name></country><country name="Suède"><region name="Svealand"><name sortKey="Botling, Johan" sort="Botling, Johan" uniqKey="Botling J" first="Johan" last="Botling">Johan Botling</name></region></country><country name="Japon"><noRegion><name sortKey="Hiroshima, Kenzo" sort="Hiroshima, Kenzo" uniqKey="Hiroshima K" first="Kenzo" last="Hiroshima">Kenzo Hiroshima</name></noRegion><name sortKey="Ishikawa, Yuichi" sort="Ishikawa, Yuichi" uniqKey="Ishikawa Y" first="Yuichi" last="Ishikawa">Yuichi Ishikawa</name><name sortKey="Keino, Naoto" sort="Keino, Naoto" uniqKey="Keino N" first="Naoto" last="Keino">Naoto Keino</name><name sortKey="Matsuno, Yoshihiro" sort="Matsuno, Yoshihiro" uniqKey="Matsuno Y" first="Yoshihiro" last="Matsuno">Yoshihiro Matsuno</name><name sortKey="Minami, Yuko" sort="Minami, Yuko" uniqKey="Minami Y" first="Yuko" last="Minami">Yuko Minami</name><name sortKey="Motoi, Noriko" sort="Motoi, Noriko" uniqKey="Motoi N" first="Noriko" last="Motoi">Noriko Motoi</name><name sortKey="Noguchi, Masayuki" sort="Noguchi, Masayuki" uniqKey="Noguchi M" first="Masayuki" last="Noguchi">Masayuki Noguchi</name><name sortKey="Yatabe, Yasushi" sort="Yatabe, Yasushi" uniqKey="Yatabe Y" first="Yasushi" last="Yatabe">Yasushi Yatabe</name><name sortKey="Yoshida, Akihiko" sort="Yoshida, Akihiko" uniqKey="Yoshida A" first="Akihiko" last="Yoshida">Akihiko Yoshida</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Nicholson, Andrew G" sort="Nicholson, Andrew G" uniqKey="Nicholson A" first="Andrew G" last="Nicholson">Andrew G. Nicholson</name></region><name sortKey="Kerr, Keith" sort="Kerr, Keith" uniqKey="Kerr K" first="Keith" last="Kerr">Keith Kerr</name></country><country name="Canada"><noRegion><name sortKey="Tsao, Ming Sound" sort="Tsao, Ming Sound" uniqKey="Tsao M" first="Ming-Sound" last="Tsao">Ming-Sound Tsao</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Warth, Arne" sort="Warth, Arne" uniqKey="Warth A" first="Arne" last="Warth">Arne Warth</name></region><name sortKey="Buettner, Reinhard H" sort="Buettner, Reinhard H" uniqKey="Buettner R" first="Reinhard H" last="Buettner">Reinhard H. Buettner</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Chen, Gang" sort="Chen, Gang" uniqKey="Chen G" first="Gang" last="Chen">Gang Chen</name></noRegion></country><country name="Argentine"><noRegion><name sortKey="Poleri, Claudia" sort="Poleri, Claudia" uniqKey="Poleri C" first="Claudia" last="Poleri">Claudia Poleri</name></noRegion></country><country name="Italie"><region name="Lombardie"><name sortKey="Pelosi, Giuseppe" sort="Pelosi, Giuseppe" uniqKey="Pelosi G" first="Giuseppe" last="Pelosi">Giuseppe Pelosi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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